• All motifs sorted by activity significance
• All samples sorted alphabetically
• Mean activities

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
• Download the whole report

Motif ID: MEF2{A,B,C,D}.p2

Z-value: 2.328

---

Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr10_+_69539255	11.876	NM_032578	MYPN	myopalladin
chr12_+_79625538	8.596	NM_002469	MYF6	myogenic factor 6 (herculin)
chr5_+_155686333	8.386	NM_000337 NM_001128209 NM_172244	SGCD	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chr2_+_88148413	7.807	NM_198274	SMYD1	SET and MYND domain containing 1
chr10_-_75085754	7.694	NM_001114133	SYNPO2L	synaptopodin 2-like
chr7_-_41709191	7.065	NM_002192	INHBA	inhibin, beta A
chr4_+_169654742	7.006	NM_001166108 NM_016081	PALLD	palladin, cytoskeletal associated protein
chr15_-_68781662	6.976	NM_001008224	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats
chr10_-_75080784	6.647	NM_024875	SYNPO2L	synaptopodin 2-like
chr12_-_55931172	6.282	NM_145064	STAC3	SH3 and cysteine rich domain 3
chr2_-_190635566	6.268	NM_005259	MSTN	myostatin
chr6_-_139654807	6.080	NM_153235	TXLNB	taxilin beta
chrX_-_21686079	5.849	NM_014332	SMPX	small muscle protein, X-linked
chr5_+_53787187	5.754	NM_006308	HSPB3	heat shock 27kDa protein 3
chr10_-_69095362	5.553	NM_001127384	CTNNA3	catenin (cadherin-associated protein), alpha 3
chr10_+_50177192	5.349	NM_001135196 NM_199459	C10orf71	chromosome 10 open reading frame 71
chr3_-_39209075	5.297	NM_194293 NM_001198621	XIRP1	xin actin-binding repeat containing 1
chr2_-_210876560	5.194	NM_079422	MYL1	myosin, light chain 1, alkali; skeletal, fast
chr8_+_67201684	5.023	NM_033058 NM_184085 NM_184086 NM_184087	TRIM55	tripartite motif containing 55
chr5_-_111119846	4.752	NM_001142483	C5orf13	chromosome 5 open reading frame 13
chr16_+_14187965	4.751		MKL2	MKL/myocardin-like 2
chr1_-_199657468	4.745	NM_003281	TNNI1	troponin I type 1 (skeletal, slow)
chr20_+_11846536	4.666	NM_014962	BTBD3	BTB (POZ) domain containing 3
chr2_-_179623030	4.537	NM_173648	CCDC141	coiled-coil domain containing 141
chr2_-_105421661	4.499	NM_201557	FHL2	four and a half LIM domains 2
chr2_-_162808123	4.433	NM_004460	FAP	fibroblast activation protein, alpha
chr11_-_19180092	4.382	NM_001127656 NM_003476	CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)
chrX_-_77801480	4.328	NM_152694	ZCCHC5	zinc finger, CCHC domain containing 5
chr6_-_76259976	4.084	NM_015687	FILIP1	filamin A interacting protein 1
chr3_+_35696119	4.055	NM_001025068 NM_001025069	ARPP21	cAMP-regulated phosphoprotein, 21kDa
chr2_+_238712101	4.026	NM_198582	KLHL30	kelch-like 30 (Drosophila)
chr7_+_18501876	4.016	NM_014707 NM_178423	HDAC9	histone deacetylase 9
chr1_-_154727014	3.909		MEF2D	myocyte enhancer factor 2D
chr2_+_170074457	3.897	NM_006063	KBTBD10	kelch repeat and BTB (POZ) domain containing 10
chr8_+_1980564	3.805	NM_003970	MYOM2	myomesin (M-protein) 2, 165kDa
chr4_-_23500706	3.774	NM_013261	PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr16_+_31132842	3.725	NM_001008274	TRIM72	tripartite motif containing 72
chr3_+_35658852	3.675	NM_016300	ARPP21	cAMP-regulated phosphoprotein, 21kDa
chr3_-_102194938	3.662	NM_015429	ABI3BP	ABI family, member 3 (NESH) binding protein
chr1_-_199613406	3.632		TNNT2	troponin T type 2 (cardiac)
chr15_+_76345577	3.607	NM_001130183	DNAJA4	DnaJ (Hsp40) homolog, subfamily A, member 4
chr1_-_199613427	3.551	NM_000364 NM_001001430 NM_001001431 NM_001001432	TNNT2	troponin T type 2 (cardiac)
chr10_+_80569464	3.545		ZMIZ1	zinc finger, MIZ-type containing 1
chr8_-_72431274	3.518	NM_172058 NM_172059 NM_172060	EYA1	eyes absent homolog 1 (Drosophila)
chr11_-_85107569	3.453	NM_206929	SYTL2	synaptotagmin-like 2
chr5_-_142057692	3.439	NM_001144934 NM_001144935	FGF1	fibroblast growth factor 1 (acidic)
chr20_+_19903778	3.426		RIN2	Ras and Rab interactor 2
chr4_+_120276386	3.425	NM_016599	MYOZ2	myozenin 2
chr17_-_24491521	3.332		MYO18A	myosin XVIIIA
chr17_-_31548167	3.304	NM_001001437 NM_021006	CCL3L3 CCL3 CCL3L1	chemokine (C-C motif) ligand 3-like 3 chemokine (C-C motif) ligand 3 chemokine (C-C motif) ligand 3-like 1
chr6_+_42896771	3.277	NM_015349	KIAA0240	KIAA0240
chr11_-_62213577	3.258		LRRN4CL	LRRN4 C-terminal like
chr15_+_61676604	3.175	NM_203373	FBXL22	F-box and leucine-rich repeat protein 22
chr6_-_130224108	3.173	NM_001010876	C6orf191	chromosome 6 open reading frame 191
chr5_-_83052606	3.112	NM_001884	HAPLN1	hyaluronan and proteoglycan link protein 1
chr3_+_8750485	3.083	NM_033337 NM_001234	CAV3	caveolin 3
chr12_-_21985433	3.045		ABCC9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr16_+_82885821	3.033	NM_021197	WFDC1	WAP four-disulfide core domain 1
chr7_-_113346284	2.933	NM_002711	PPP1R3A	protein phosphatase 1, regulatory (inhibitor) subunit 3A
chr12_+_15590811	2.917		PTPRO	protein tyrosine phosphatase, receptor type, O
chr1_-_115039614	2.909	NM_000036 NM_001172626	AMPD1	adenosine monophosphate deaminase 1
chr2_+_102744921	2.902	NM_144632	TMEM182	transmembrane protein 182
chr10_+_111755715	2.895	NM_019903	ADD3	adducin 3 (gamma)
chr14_+_23670514	2.892	NM_203402	FITM1	fat storage-inducing transmembrane protein 1
chr3_+_129117007	2.873		KBTBD12	kelch repeat and BTB (POZ) domain containing 12
chr4_+_114190233	2.856	NM_001148 NM_020977	ANK2	ankyrin 2, neuronal
chr9_+_96806235	2.852		C9orf3	chromosome 9 open reading frame 3
chr14_+_99309688	2.838		EML1	echinoderm microtubule associated protein like 1
chr21_-_18697829	2.825	NM_002772	TMPRSS15	transmembrane protease, serine 15
chr6_+_131613196	2.816	NM_004842 NM_138633	AKAP7	A kinase (PRKA) anchor protein 7
chr7_+_18502342	2.781	NM_058176 NM_178425	HDAC9	histone deacetylase 9
chr1_+_154478574	2.764	NM_199173	BGLAP	bone gamma-carboxyglutamate (gla) protein
chr17_-_10500189	2.763	NM_002470	MYH3	myosin, heavy chain 3, skeletal muscle, embryonic
chr15_+_66695932	2.758	NM_001190456	CORO2B	coronin, actin binding protein, 2B
chr16_-_31347151	2.735	NM_005205	COX6A2	cytochrome c oxidase subunit VIa polypeptide 2
chr6_+_53991672	2.728	NM_138569	C6orf142	chromosome 6 open reading frame 142
chr13_-_59223074	2.723
chr7_+_93862137	2.716		COL1A2 PLAG1	collagen, type I, alpha 2 pleiomorphic adenoma gene 1
chr1_+_144124547	2.692	NM_145277 NM_202004 NM_213652 NM_213653	HFE2	hemochromatosis type 2 (juvenile)
chrX_-_11194015	2.670	NM_013423	ARHGAP6	Rho GTPase activating protein 6
chr1_-_16217025	2.645		HSPB7	heat shock 27kDa protein family, member 7 (cardiovascular)
chr12_+_15590552	2.612	NM_030668 NM_030669 NM_030670 NM_030671	PTPRO	protein tyrosine phosphatase, receptor type, O
chr6_+_136214495	2.578	NM_018945	PDE7B	phosphodiesterase 7B
chr10_+_88418243	2.560	NM_001080116 NM_001080114 NM_001080115 NM_001171611 NM_007078	LDB3	LIM domain binding 3
chr4_+_146820805	2.510	NM_001080531	C4orf51	chromosome 4 open reading frame 51
chr3_-_11585264	2.470	NM_001128221	VGLL4	vestigial like 4 (Drosophila)
chr12_-_242255	2.468	NM_001190997 NM_016615	SLC6A13	solute carrier family 6 (neurotransmitter transporter, GABA), member 13
chr12_+_118100977	2.456	NM_014365	HSPB8	heat shock 22kDa protein 8
chr11_-_62213946	2.451	NM_203422	LRRN4CL	LRRN4 C-terminal like
chr17_-_26672757	2.435	NM_001003927 NM_014210	EVI2A	ecotropic viral integration site 2A
chr22_+_24468168	2.393		MYO18B	myosin XVIIIB
chr21_-_35174742	2.353		RUNX1	runt-related transcription factor 1
chr1_-_202595666	2.339	NM_014935	PLEKHA6	pleckstrin homology domain containing, family A member 6
chr17_-_10265991	2.294	NM_002472	MYH8	myosin, heavy chain 8, skeletal muscle, perinatal
chr1_+_12325632	2.255		VPS13D	vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr2_+_220007943	2.215	NM_005876	SPEG	SPEG complex locus
chr17_+_42641712	2.158	NM_002476	MYL4	myosin, light chain 4, alkali; atrial, embryonic
chr4_-_1185144	2.155		LOC100130872	hypothetical LOC100130872
chr22_+_24468110	2.138	NM_032608	MYO18B	myosin XVIIIB
chr3_-_48573556	2.133		PFKFB4	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chrX_-_138742050	2.130	NM_001010986 NM_173694	ATP11C	ATPase, class VI, type 11C
chr17_+_39603599	2.091	NM_080863	ASB16	ankyrin repeat and SOCS box containing 16
chr8_-_122722674	2.061	NM_005328	HAS2	hyaluronan synthase 2
chr17_-_10362583	2.046	NM_005963	MYH1	myosin, heavy chain 1, skeletal muscle, adult
chr22_-_49363711	2.042	NM_004377 NM_152246 NM_001145134 NM_001145135 NM_001145136 NM_152245	CPT1B	carnitine palmitoyltransferase 1B (muscle)
chr3_-_115825742	2.032	NM_001164347	ZBTB20	zinc finger and BTB domain containing 20
chr2_+_151922350	2.027	NM_007115	TNFAIP6	tumor necrosis factor, alpha-induced protein 6
chr5_+_244625	2.026	NM_001080478	LRRC14B	leucine rich repeat containing 14B
chr6_-_169395847	2.017		THBS2	thrombospondin 2
chr11_+_5667494	2.013	NM_006074	TRIM22	tripartite motif containing 22
chr10_+_91082218	2.006	NM_001031683	IFIT3	interferon-induced protein with tetratricopeptide repeats 3
chr1_+_26220852	1.989	NM_004455	EXTL1	exostoses (multiple)-like 1
chr2_-_236837726	1.978	NM_212556	ASB18	ankyrin repeat and SOCS box containing 18
chr1_+_26220895	1.972		EXTL1	exostoses (multiple)-like 1
chr9_+_115367122	1.968	NM_134427	RGS3	regulator of G-protein signaling 3
chr21_+_29439768	1.960		C21orf7	chromosome 21 open reading frame 7
chr10_+_86174665	1.913		FAM190B	family with sequence similarity 190, member B
chr2_+_85774924	1.913	NM_006433 NM_012483	GNLY	granulysin
chr1_+_40508336	1.900		ZMPSTE24	zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr7_-_76667045	1.899	NM_006682	FGL2	fibrinogen-like 2
chrX_+_152699616	1.896	NM_001170760 NM_001170761 NM_014370	SRPK3	SRSF protein kinase 3
chr8_-_62764839	1.871	NM_001164750 NM_001164751 NM_001164752 NM_001164753 NM_020164 NM_032467 NM_032468	ASPH	aspartate beta-hydroxylase
chr1_+_242283129	1.870	NM_006352	ZNF238	zinc finger protein 238
chr3_+_137224266	1.867	NM_181897	PPP2R3A	protein phosphatase 2, regulatory subunit B'', alpha
chr2_+_201182187	1.867		AOX1	aldehyde oxidase 1
chr12_-_68379331	1.856	NM_032735	BEST3	bestrophin 3
chr12_-_49689295	1.851	NM_001174130	SLC11A2	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr10_+_91142301	1.839	NM_001548	IFIT1	interferon-induced protein with tetratricopeptide repeats 1
chr19_+_23091616	1.839		ZNF730	zinc finger protein 730
chr3_+_100840129	1.832	NM_001850 NM_020351	COL8A1	collagen, type VIII, alpha 1
chr1_+_144236346	1.829	NM_003637	ITGA10	integrin, alpha 10
chr16_-_30929217	1.828	NM_052874	STX1B	syntaxin 1B
chr13_-_50315832	1.827	NM_198989	DLEU7	deleted in lymphocytic leukemia, 7
chr1_-_151784889	1.825	NM_002961 NM_019554	S100A4	S100 calcium binding protein A4
chr10_+_88418147	1.821	NM_001171610	LDB3	LIM domain binding 3
chr1_+_144236398	1.821		ITGA10	integrin, alpha 10
chr16_-_49205063	1.808
chr3_+_42702014	1.799	NM_152393	KBTBD5	kelch repeat and BTB (POZ) domain containing 5
chr9_+_134884627	1.789		EEF1A1	eukaryotic translation elongation factor 1 alpha 1
chr18_+_12397894	1.783	NM_001142405 NM_006553	SLMO1	slowmo homolog 1 (Drosophila)
chr1_-_229071957	1.774	NM_001136494	C1orf198	chromosome 1 open reading frame 198
chr5_-_42847716	1.767	NM_001085486 NM_001093726 NM_005410	SEPP1	selenoprotein P, plasma, 1
chr4_+_111053488	1.760	NM_001178130 NM_001178131 NM_001963	EGF	epidermal growth factor
chr10_-_69125932	1.760	NM_013266	CTNNA3	catenin (cadherin-associated protein), alpha 3
chr7_+_30917939	1.752	NM_198098	AQP1	aquaporin 1 (Colton blood group)
chr5_-_140875591	1.742		DIAPH1	diaphanous homolog 1 (Drosophila)
chr8_-_23768242	1.738	NM_003155	STC1	stanniocalcin 1
chr2_-_217268492	1.721	NM_000599	IGFBP5	insulin-like growth factor binding protein 5
chr13_+_110637173	1.719	NM_001113513	ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7
chr5_+_121493113	1.699	NM_207317	ZNF474	zinc finger protein 474
chr3_+_50291521	1.695	NM_153215	C3orf45	chromosome 3 open reading frame 45
chr6_-_169395972	1.695	NM_003247	THBS2	thrombospondin 2
chr4_-_186934059	1.676	NM_001145673	SORBS2	sorbin and SH3 domain containing 2
chr4_-_177427252	1.675	NM_080874	ASB5	ankyrin repeat and SOCS box containing 5
chr3_-_113842652	1.673	NM_199511 NM_199512	CCDC80	coiled-coil domain containing 80
chr15_+_76171981	1.643	NM_001101404	SH2D7	SH2 domain containing 7
chr2_+_44356100	1.639	NM_000341	SLC3A1	solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1
chr2_-_165768798	1.620	NM_001081676 NM_001081677 NM_006922	SCN3A	sodium channel, voltage-gated, type III, alpha subunit
chrX_-_142549984	1.608	NM_001184750	SLITRK4	SLIT and NTRK-like family, member 4
chr12_-_49689255	1.607		SLC11A2	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr3_-_193928038	1.591	NM_004113	FGF12	fibroblast growth factor 12
chr17_-_39094787	1.587	NM_001040002	MEOX1	mesenchyme homeobox 1
chr5_+_132037271	1.580	NM_000589 NM_172348	IL4	interleukin 4
chr6_-_46401363	1.568	NM_005822	RCAN2	regulator of calcineurin 2
chr4_-_138673078	1.566	NM_019035	PCDH18	protocadherin 18
chr5_+_140532385	1.557	NM_018940	PCDHB7	protocadherin beta 7
chr11_+_5667392	1.508		TRIM22	tripartite motif containing 22
chr14_+_77939845	1.493	NM_004796	NRXN3	neurexin 3
chr17_+_42641426	1.487	NM_001002841	MYL4	myosin, light chain 4, alkali; atrial, embryonic
chr20_+_60558104	1.480	NM_178463	C20orf166	chromosome 20 open reading frame 166
chr22_+_34109095	1.477		HMOX1	heme oxygenase (decycling) 1
chr8_+_40130143	1.469	NM_020130	C8orf4	chromosome 8 open reading frame 4
chr9_+_5440455	1.461	NM_014143	CD274	CD274 molecule
chr22_-_16060485	1.449	NM_177405	CECR1	cat eye syndrome chromosome region, candidate 1
chr12_-_25041639	1.444	NM_001101339	C12orf77	chromosome 12 open reading frame 77
chr14_+_95792299	1.439	NM_000710	BDKRB1	bradykinin receptor B1
chr3_-_57301749	1.437	NM_001142733	ASB14	ankyrin repeat and SOCS box containing 14
chr5_-_66528330	1.435	NM_005582	CD180	CD180 molecule
chr1_+_201364050	1.430		ADORA1	adenosine A1 receptor
chr19_-_52427698	1.427	NM_001127240 NM_001127241 NM_001127242	BBC3	BCL2 binding component 3
chr1_-_116112853	1.418		CASQ2	calsequestrin 2 (cardiac muscle)
chr9_-_14769530	1.412	NM_001177704	FREM1	FRAS1 related extracellular matrix 1
chr1_+_158352143	1.411	NM_000702	ATP1A2	ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr3_-_113842553	1.407		CCDC80	coiled-coil domain containing 80
chr2_+_96818048	1.396		CNNM4	cyclin M4
chr3_-_133236447	1.395	NM_130808	CPNE4	copine IV
chr19_+_43847049	1.393
chr2_+_233099113	1.383	NM_000751	CHRND	cholinergic receptor, nicotinic, delta
chr2_+_69055208	1.361	NM_019617	GKN1	gastrokine 1
chr1_-_116112684	1.356		CASQ2	calsequestrin 2 (cardiac muscle)
chr13_-_44673174	1.354	NM_198404	KCTD4	potassium channel tetramerisation domain containing 4
chr1_-_31618405	1.331	NM_004102	FABP3	fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr1_+_213245507	1.303	NM_001017424	KCNK2	potassium channel, subfamily K, member 2
chr1_-_116112921	1.302	NM_001232	CASQ2	calsequestrin 2 (cardiac muscle)
chr5_-_142045770	1.300	NM_000800	FGF1	fibroblast growth factor 1 (acidic)
chr2_+_33514896	1.297	NM_170672	RASGRP3	RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr8_-_27906287	1.288	NM_173833	SCARA5	scavenger receptor class A, member 5 (putative)
chr7_-_11838260	1.267	NM_015204	THSD7A	thrombospondin, type I, domain containing 7A
chr1_+_144183811	1.265		ANKRD34A	ankyrin repeat domain 34A
chr1_-_100416358	1.229	NM_144620	LRRC39	leucine rich repeat containing 39

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
3.10	7.65e-07	GO:0007517	muscle organ development
2.67	2.13e-06	GO:0061061	muscle structure development
2.88	7.58e-05	GO:0003012	muscle system process
2.80	9.99e-03	GO:0060537	muscle tissue development
2.57	1.37e-02	GO:0006936	muscle contraction
4.47	4.73e-02	GO:0030049	muscle filament sliding
4.47	4.73e-02	GO:0033275	actin-myosin filament sliding

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
4.41	2.79e-11	GO:0030016	myofibril
4.28	3.20e-11	GO:0043292	contractile fiber
4.39	7.28e-11	GO:0044449	contractile fiber part
4.45	1.46e-09	GO:0030017	sarcomere
3.76	2.02e-02	GO:0031674	I band
1.46	4.09e-02	GO:0044421	extracellular region part

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
9.39	3.49e-02	GO:0042805	actinin binding
1.69	3.69e-02	GO:0008092	cytoskeletal protein binding
1.90	3.88e-02	GO:0003779	actin binding
3.84	4.92e-02	GO:0008307	structural constituent of muscle